Solid phase synthesis and NMR conformational studies on cyclic decapeptide template molecule

Biopolymers ◽  
1999 ◽  
Vol 49 (7) ◽  
pp. 565-574 ◽  
Author(s):  
Zheng-Hong Peng
2001 ◽  
pp. 226-227
Author(s):  
Hoai Huong Nguyen ◽  
Diana Imhof ◽  
Brigitte Schlegel ◽  
Albert Härtl ◽  
Matthias Kronen ◽  
...  

1999 ◽  
Vol 77 (8) ◽  
pp. 1394-1404 ◽  
Author(s):  
Zhenghong Peng

We report the synthesis and conformational analysis of a series of cyclic and bicyclic decapeptide templates for combinatorial chemistry. The peptides were synthesized via solid phase synthesis and followed by solution cyclization. The conformation of the peptides was studied by proton NMR spectroscopy in DMSO and in TFE-water. The structure of the peptide template was calculated with the program DIANA and followed by SA from the NMR experimental constraints. The peptide adopts a fold comprising two β-strands and two type II β-turns. The design of such a restained cyclic decapeptide template will be discussed along with Template Assembled Synthetic Proteins (TASP).Key words: solid phase peptide synthesis, cyclic decapeptide, NMR, conformational analysis, β-sheet.


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